Figure 5. NKG2A^−/− mice demonstrate greater lung damage from enhanced inflammation during acute influenza infection.

Mice were intranasally infected with a sub-lethal dose of influenza A/PR8/34. On day 10 post-infection, mice were euthanized by anesthesia overdose and exsanguination. Lungs were process as in materials and methods for histological sections, slides were H & E stained and evaluated for histopathological damage. Percent of total area of damaged lung per 4× field was calculated for each lung slice. Data is presented as % inflamed lung. Data is representative of two distinct experiments of 2–4 mice per group. **** p<0.0001.