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. 2014 Sep 24;9(9):e107895. doi: 10.1371/journal.pone.0107895

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© 2014 Vishavkarma et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a) Changes in cell and nuclear projected areas after microtubule disruption using Nocodazole and actin depolymerisation using Latrunculin-A. (b, c) Variation in the two areas after treatment with blebbistatin to deactivate myosin-II. Note that substrate sensitivity is significantly diminished after mysosin-II inhibition. Further, for all drug treatments, a change in cell area causes a correlated change in nuclear area. All the values for the cell area and nuclear projected area are taken from over 80–100 cells in each case and the error bars in the plots represent standard error. Student t-test values are and the comparison is with control for (a) and with 65 kPa substrate for (b).

Inline graphic — (a) Changes in cell and nuclear projected areas after microtubule disruption using Nocodazole and actin depolymerisation using Latrunculin-A. (b, c) Variation in the two areas after treatment with blebbistatin to deactivate myosin-II. Note that substrate sensitivity is significantly diminished after mysosin-II inhibition. Further, for all drug treatments, a change in cell area causes a correlated change in nuclear area. All the values for the cell area and nuclear projected area are taken from over 80–100 cells in each case and the error bars in the plots represent standard error. Student t-test values are and the comparison is with control for (a) and with 65 kPa substrate for (b).