Table 1.

Target genes of the Notch signaling pathways

Gene	Role	Tissues	Comments
cyclin D1, cyclin A , p21, p27,	Cell cycle regulators	Hepatocellular cancer, renal cancer	[9,10]
c-myc, NF-κB2 , Akt, mTOR,	Cell proliferation and survival	Keratinocytes, liver, T-ALL,	[11-16]
Hes1, Hes6	Embryonic development	Embryonic neural progenitor cell, human pluripotent stem cells	[17,18]
VEGF, VEGFR-2	Angiopoiesis	Osteosarcoma, endothelial and neural cells.	[19,20]
MMP-9, MMP-2	Invasion and metastasis	Osteosarcoma, pancreatic cancer	[19,21]