Table 2.
Available data of the animals, histological classification of the canine gastric tissues and main immunohistochemical findings
| Case | Breed | Gender/Age (years) | Histological diagnosis | Helicobacter spp. | COX-2 | KI-67 (%) | p53 | CDX2 | |
|---|---|---|---|---|---|---|---|---|---|
| SE | DG | ||||||||
| 1 | Rottweiler | M/12 | Hyperplastic polyp | +++2 | >75%/+++ | >75%/ +++ | 36,12,3 | - | - |
| 2 | Irish Setter | F/12 | Hyperplastic polyp | +++2 | >75%/+++ | >75%/+++ | 31,42,3 | - | - |
| 3 | Poodle | F/12 | Hyperplastic polyp | +++2 | >75%/ +++ | >75%/+++ | 32,12,3 | - | - |
| 4 | Argentine Mastiff | F/9 | Hyperplastic polyp | ++2 | >75%/+++ | >75%/ +++ | 28,92,3 | - | - |
| 5 | Rottweiler | F/14 | Hyperplastic polyp | +2 | >75%/+++ | >75%/+++ | 30,92,3 | - | - |
| 6 | Mixed breed | F/16 | Hyperplastic polyp | ++2 | >75%/+++ | >75%/+++ | 16,72,3 | - | - |
| 7 | Poodle | M/13 | Inflammatory polyp | ++2 | >75%/+++ | >75%/+++ | 31,52,3 | - | - |
| 8 | German Shepherd | M/9 | Inflammatory polyp | ++2 | >75%/+++ | >75%/+++ | 10,82 | - | - |
| 9 | Boxer | M/10 | Hyperplastic polyp | +1 | >75%/+++ | >75%/+++ | 4,62 | - | - |
| 10 | Mixed breed | M/2 | NGM | 0 | >75%/+++ | >75%/+ | 18,32 | - | - |
| 11 | Poodle cross | F/15 | NGM | 0 | >75%/+++ | >75%/++ | 23,62 | - | - |
| 12 | Boxer | M/4 | NGM | 0 | >75%/+++ | >75%/+ | 15,62 | - | - |
| 13 | Mixed breed | M/8 | NGM | 0 | >75%/+++ | >75%/++ | 22,82 | - | - |
M male, F female.
COX-2: SE, surface epithelium; DG, deeper glands. >75% of immunopositive cells, + weak, ++ moderate, +++ strong intensity.
Helicobacter spp.: + few; ++ moderate number; +++ large number of organisms. The bacteria location 0, absent; 1 = on mucosal surface and within gastric pits; 2 = 1+ lumen of the gastric glands; KI-67: zone 2, isthmus and zone 3, gland base; p53 and CDX2: −, negative.