Table 2.
Clinical trials have been conducted on the impact of other herbs on primary dysmenorrheal (PD).
| Jdad score | Side effects and possible reaction | results | Measure | Participants | Control group | Experimental group | method | Authors (year) | Ref. | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 5 | Uncomplicated | Herbal extract was more effective than mefenamic acid in pain reduction | VAS | 180 students 18-27 years old | placebo | One group 500 mg/TID Menstrugol® (saffron, celery and aniseed) for first 3 days of menstruation, another group Mefenamic acid 250 mg/TID | double-blind, randomized, placebo controlled trial 3 cycles |
Khodakarami (2009) |
23 | |||||||||
| 4 | Uncomplicated | There was no difference between the two groups. | VAS | 161 students 17-30 years old | Placebo | Menstrugol® (saffron, celery and aniseed)/TID for first 3 days of menstruation, another group Mefenamic acid 250 mg/ TID | double-blind, randomized, placebo controlled trial, 3 cycles | Khodayari (2004) | 24 | |||||||||
| 4 | Two patients were excluded due to nausea. | 70% reduction in pain intensity in experimental group versus 6% in control. | VAS | 60 students with moderate or severe dysmenorrhea | placebo 40 drops daily for 3 months from the 1st day of menstruation | Vitagnus® (Vitex agnus-castus) 40 drops daily for 3 months from the 1st day of menstruation | double-blind, randomized, placebo controlled trial, 3 cycles | Shahhosseini (2006) |
53 | |||||||||
| 5 | Uncomplicated | There was no difference between the 2 groups. | VMSS | 150 students | One group Mefenamic acid 250 mg/QID, another group Ibuprofen 400 mg/QID | 250 mg ginger/QID for 3 days | double-blind, randomized, placebo controlled trial, 3 cycles | Ozgoli (2007) |
18 | |||||||||
| 4 | Uncomplicated | Reduction the severity of dysmenorrhea and signs and pain killer and menstrual bleeding | VAS | 72 single female students 18-26 years old with moderate and sever PD | Baby oil | A topical lotion Menastil daily maximum of 3 doses in the first 2 days of menstrual cycles within 2 | double-blind, randomized, placebo controlled trial, 2 cycles | Kariman (2007) |
21 | |||||||||
| 5 | Uncomplicated | Reduction the severity of dysmenorrhea in valerian group than placebo. The total scores of the systemic manifestations decreased after the intervention, but there was no significant difference between the groups, with the exception for syncope. |
VAS and VMSS |
100 students 18-24 years | Placebo (starch) 3 days beginning at the onset of menstruation | 250 mg valerian root/TID for 3 days beginning at the onset of menstruation, for 2 consecutive menstrual cycles | randomized clinical trial cycles 2 |
Mirabi (2011) |
32 | |||||||||
| 4 | Not mentioned | Zataria multiflora 1% or 2%, compared with placebo in reducing dysmenorrhea | VAS and VMSS |
108 students 18-25 years old with dysmenorrhea (moderate or severe) | Placebo | One group 25 drop Zataria multiflora 1%, another group 25 drop Z. multiflora 2% onset dysmenorea | double-blind, randomized, placebo controlled trial, 3 cycles | Irvani (2009) |
46 | |||||||||
| 3 | Uncomplicated | There was no difference between the 2 groups. | Questionnaire, VMSS and Criterion Andrish Mylsvm |
100 single female students 18-22 years old who experienced moderate–severe dysmenorrhea. | - | 1st cycle without drug, for 2nd cycle 40 drops Mentha piperita every hour in case, another group 400 mg Ibuprofen every 4 hours in first 3 days of menstruation | Randomized clinical trial, 2 cycles |
Amoyi-rokn abaad (2012) |
51 | |||||||||
| 5 | Uncomplicated | Reduction in pain compared to placebo group, cinnamon Higher. Systemic symptoms were not different between the two groups |
Questionnaire and VMSS |
47 single female students 18-30 years old who experienced moderate–severe dysmenorrhea. |
Placebo | 5 capsules 420 mg cinnamon for first 3 days of menstruation in 2 consecutive cycles | double-blind, randomized, placebo controlled trial, 2 cycles | Akhavan-amjadi (2009) |
37 | |||||||||
| Cannot be calculated | Uncomplicated | During the time of dysmenorea and pain Intensity after consumption Stachys lvandulifolia significant difference was observed. Systemic symptoms, the scores did not differ from factors other than changes in the nervous. | VAS and VMSS |
50 single female students 18-25 years old | Stachys lvandulifolia (5 g infusion)/TID in starting bleeding | Clinical trial, 2 cycles | Mirabi (2012) |
42 | ||||||||||
| 4 | Uncomplicated | There was no difference between the 2 groups. | Questionnaire and VAS | 102 students | 1st group valerian 250 mg within 2 to 3 days of menstruation cycles, and the 2nd group 250 mg Mefenamic acid | Randomized clinical trial | Jenabi (2009) |
27 | ||||||||||
| 5 | Uncomplicated | The duration and severity of primary dysmenorrhea in ginger. To be significantly reduced compared with placebo. |
VAS and VMSS |
Mean age 21 years, 78 female students with moderate to severe dysmenorrhea | Placebo | 500 mg ginger TID in first 3 days of menstruation | triple-blind, randomized, placebo controlled trial | Rahnema (2011) |
19 | |||||||||
| 5 | Two patients were excluded due to nausea | Pain severity in Echinophora platyloba, to be significantly reduced compared with placebo. | VAS | 60 students | Placebo |
Echinophora platyloba extract 30 drops TID for 3 days before the start of menstruation and in the first 3 day of menstruation |
A clinical trial before-after 2 cycles | Delaram (2010) |
56 | |||||||||
| 5 | Uncomplicated | In both Mefenamic acid and Matricaria chamomilla (MC), menstrual pain decreased after 2 cycles of treatment, but this reduction was seen in MC. | Questionnaire and VAS | 80 single female students 20-30 years old who experienced moderate–severe dysmenorrhea |
Matricaria chamomilla (400 mg) within 1st day or a day before the start of menstrual bleeding for 2 consecutive cycles and for 3 days 800 mg QID in each, and the 2nd group with the same group of 500 mg Mefenamic acid in the same way before | triple-blind randomized cross over clinical trial | Modaress (2011) |
28 | ||||||||||
| Cannot be calculated | Uncomplicated | Among consumer groups Cuminum cyminum, 2 doses TID had the lowest pain. Also reduction in pain intensity between the 1st and 2nd cycles of treatment. Significantly differences between the intervention groups than previously reported. | VMSS | 100 students 14-18 years old | 5 groups: three groups consumed C. cyminum (65 mg/TID, 130 mg/TID and 65 mg per 12 h), one group consumed placebo and the last group took Mefenamic acid | Randomized clinical trial 3 cycles | Tavasoli (2002) |
22 | ||||||||||
| Cannot be calculated | Not mentioned | Pain during the first 3 days of treatment cycles compared with cycles without treatment significantly reduced. | Questionnaire and VAS |
70 students with moderate dysmenorrhea | 1 capsule of Achillea willhemsii extract TID | Randomized clinical trial | Satar-zadeh (2009) |
59 | ||||||||||
| Cannot be calculated | Uncomplicated | After consumption Stachys lvandulifolia significant difference was observed. The total scores of the systemic manifestations decreased. Decreased after the intervention, but there was no significant difference between the groups, with the exception for nervous. |
VAS and VMSS | 50 single female students 18-25 years old | 10 g of infused plant powder TID (2 days before and 3 days after the onset of pain) | Clinical trial, 3 cycles | Olfati (2011) |
41 | ||||||||||