Table 6.
(A). Multiple regression analysis of 32 factorial batches for viscosity, bioadhesion potential and Q6h
| Source | Degree of freedom | Sum square | Mean square | F-value | Prob>F | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Y 1 = Viscosity | |||||||||||||
| Model | 2 | 8.370E+005 | 4.185E+005 | 23.25 | 0.0015 | ||||||||
| X1 | 1 | 5.828E+005 | 5.828E+005 | 32.38 | 0.0013 | ||||||||
| X2 | 1 | 2.542E+005 | 2.542E+005 | 14.14 | 0.0094 | ||||||||
| R2=0.887 Adj R2=0.8476 PredR2=0.7416 SD=134.16 CV=9.45 | |||||||||||||
| Equation Y 1 =1419.44+311.67 X 1 +205.83 X 2 | |||||||||||||
| Y 5 =Bioadhesion potential | |||||||||||||
| Model | 5 | 14.69 | 2.94 | 45.34 | 0.0050 | ||||||||
| X1 | 1 | 8.17 | 8.17 | 126.00 | 0.0015 | ||||||||
| X2 | 1 | 2.67 | 2.67 | 41.14 | 0.0077 | ||||||||
| X1X2 | 1 | 2.25 | 2.25 | 34.71 | 0.0098 | ||||||||
| X12 | 1 | 1.39 | 1.39 | 21.43 | 0.0190 | ||||||||
| X22 | 1 | 0.22 | 0.22 | 3.43 | 0.1612 | ||||||||
| R2=0.986 Adj R2=0.9652 Pred R2=0.8467 SD=0.25 CV=2.24 | |||||||||||||
| Equation Y 5 = 0.11-1.17X 1 -0.67X 2 +0.75X 1 X 2 +0.83X 1 2 +0.33 X 2 2 | |||||||||||||
| Y 6 = In-vitro drug release at Q 6h | |||||||||||||
| Model | 5 | 727.34 | 145.47 | 144.56 | 0.0009 | ||||||||
| X1 | 1 | 482.57 | 482.57 | 479.57 | 0.0002 | ||||||||
| X2 | 1 | 139.50 | 139.50 | 138.63 | 0.0013 | ||||||||
| X1X2 | 1 | 3.13 | 3.13 | 3.11 | 0.1759 | ||||||||
| X12 | 1 | 101.92 | 101.92 | 101.28 | 0.0021 | ||||||||
| X22 | 1 | 0.22 | 0.22 | 0.22 | 0.6721 | ||||||||
| R2=0.9959 Adj R2=0.9890 Pred R2=0.9513 SD=1.00 CV=1.58 | |||||||||||||
| Equation Y 6 = 67.86-8.97X 1 - 4.82X 2 -0.88X 1 X 2 -7.14X 1 2 +0.33 X 2 2 | |||||||||||||
(*
Significant terms at P< 0.05).