Figure 11. Hyperpolarizing TC neurons produces a KC by decreasing the thalamocortical drive to cortex.

All TC neurons were hyperpolarized at 116pA for 300 ms. The length of TC hyperpolarization is outlined by the blue box. For the duration of TC hyperpolarization (blue asterisk), RE and TC spindling dropped (red asterisk), RE I_T became deinactivated (green asterisk), and PY spiking dropped to zero (“KC”), indicating a KC. This was followed by a rebound upstate, as marked by TC depolarization, increased RE and TC spindling above baseline levels, and high PY spiking (black arrows).