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. 2014 Sep 25;10(9):e1003823. doi: 10.1371/journal.pcbi.1003823

Figure 1. Single neuron stimulation (SNS) can stop population bursting activity in presence of type T1 plus T2 correlations.

Figure 1

A sketch of a SNS experiment for a network with type T1 plus T2 correlations is reported in (A) and (B): the neuron Inline graphic is stimulated with a DC step for a time interval Inline graphic (as shown by the red line on the top panel). Average firing rate of neuron Inline graphic (A) and network activity (B) as measured during the experiment. (C) and (D) refer to correlated and uncorrelated networks, respectively. Upper panels display the number of population bursts, PBs, delivered during SNS experiments versus the stimulated neuron, ordered accordingly to their average firing rates Inline graphic under control conditions (bottom panels). Each neuron Inline graphic was stimulated with a DC step (switching its excitability from Inline graphic to Inline graphic) for an interval Inline graphic s. The critical neurons are signaled by red circles. The number of PBs, emitted in control conditions within an interval Inline graphic s, are also displayed: red dashed lines indicate their averages, while the shaded gray areas correspond to three standard deviations. The data refer to Inline graphic mV and Inline graphic neurons.