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. 2014 Sep 25;10(9):e1004599. doi: 10.1371/journal.pgen.1004599

Table 1. Neurospora SWI/SNF subunits and knockouts.

Yeast subunits Function P value Neurospora ortholog Identity of gene deletion mutants in the whole genome knockout collection Effect of gene deletion on FRQ expression
SWP59 (ARP9) Actin related 1.6e-16 NCU08840 FGSC #18403 Reduced
FGSC #18404
SWP73 (SNF12) 5.7e-14 NCU03572 FGSC #18763 ND
SWI2 (SNF2) Core subunit, ATPase activity 4.8e-267 NCU06488 FGSC #11467 ND
heterokaryon
SNF5 Core subunit 7.4e-40 NCU00421 FGSC #11785 Reduced
FGSC #11786
SWI1 4.9e-21 NCU05891 FGSC #11904 Reduced
FGSC #11905
SWI3 Core subunit 7.6e-59 NCU08003 FGSC #21999 ND
heterokaryon
SWP82 2.3e-10 NCU03064 FGSC #19756 ND
SWP29 (TAF14/TAF30) 2.3e-46 NCU00444 FGSC #18696 ND
FGSC #18697

Neurospora homologs were recovered based on similarity to Saccharomyces SWI/SNF subunits. All listed subunits are not essential in Saccharomyces cerevisiae. P value refers to the pBLAST score of the Neurospora ortholog when the yeast protein sequence was used to probe the Neurospora genome. In Neurospora, deletions of non essential genes are available as homokaryons whereas deletions of essential genes such as swi2 and swi3 are maintained as heterokaryons in which the deletion is mixed within syncytium with nuclei containing a WT copy of the gene.