Figure 10. NF-κB subunits bind the EZH2 promoter in fibroblasts and B-cells.
(A & B) ChIP analysis of the EZH2 promoter was performed in NHD fibroblast cells using primers close to the core promoter of the EZH2 gene (A) (+596/+888) or an upstream control region (B) (−2802/−2600). Results shown are representative of a minimum of 3 separate experiments. * P≤0.05, ** P≤0.01, *** P≤0.001, **** P≤0.0001. (C) ChIP Seq data showing NF-κB subunit binding in the region of the EZH2 gene in the human EBV-transformed lymphoblastoid B-cell line (LCL) GM12878.
