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. 2014 Sep 25;9(9):e107116. doi: 10.1371/journal.pone.0107116

Figure 2. Acute effects of the SGA drugs lurasidone and olanzapine on glucose levels in adult female rats in the glucose tolerance test.

Figure 2

Animals (n = 8 per group) received a single injection of vehicle, lurasidone (0.2, 0.8 or 2.0 mg/kg, s.c) or olanzapine (10 mg/kg, s.c.) in a volume 1 ml/kg. Glucose levels were recorded prior to drug treatment in overnight-fasted rats at Time 0, and then 30 minutes following drug administration (x-axis). Immediately following this glucose measurement, all rats were subjected to a glucose tolerance test by receiving an intraperitoneal challenge injection of 1 g/ml/kg of glucose, and blood glucose levels were measured every 15 minutes for the next two hours. Total cumulative glucose levels for each treatment group are summed as the “area under the curve” during the glucose tolerance test by graph inset (top right). Values represent group means ± SEM; *indicates different from vehicle-treated animals, p<0.01; **indicates different from vehicle-treated animals, p<0.001.