Table 1. Mean concentration of fasting glucose, insulin and HOMA-IR scores in antipsychotic drug treated rats.

Antipsychotic Drug	Measure	Treatment Dose (mg/kg)
		0	0.2	0.8	2
Lurasidone	G0	5.6±0.1	5.4±0.3	5.3±0.2	5.2±0.2
	I0	10.0±0.7	10.4±0.8	9.5±0.7	10.4±0.9
	HOMA-IR	2.5±0.2	2.5±0.2	2.2±0.8	2.5±0.3
					10
Olanzapine	G0				5.5±0.2
	I0				22.9±5.4*
	HOMA-IR				5.8±1.5*

I₀ = fasting insulin levels (µU/ml); G₀ = fasting glucose levels (mmol/L); HOMA-IR = homeostasis model assessment of insulin resistance (µU·mmol)/(ml·L).

Rats were treated with three separate doses of lurasidone (0.2, 0.8 or 2.0 mg/kg), olanzapine (10 mg/kg) or vehicle. Values represented as means ± SEM at t = 30 min during the IGTT.

*indicates different from vehicle-treated animals, p<0.001.