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. 2014 Sep 25;9(9):e107995. doi: 10.1371/journal.pone.0107995

Figure 5. Tumor doubling times after three treatments with pyruvate and/or TH-302.

Figure 5

Doubling time was measured as the increase from initial tumor size, which was the tumor volume prior to treatment. A, SCCVII tumor-bearing C3H/Hen mice. Mice were treated three times on days 7–9 (Day 7 start) or days 9–11 (Day 9 start). B, HT29 tumor-bearing athymic nude mice. Mice were treated three times on days 8/10/12 (Day 8 start) or days 14/16/18 (Day 14 start). Data are mean ± SE of 5 mice. **, P<0.01, ***, P<0.001; N.S., not significant.