Table 3. Patient characteristics and mRNA expression of FcεRI α, β, and γ receptor chainsa.
α-chain | β-chain | γ-chain | TotalIgEb | NC16AIgEc | eosinophilcount | diseaseactivityd | |
healthy controls | |||||||
C493 | + | – | + | 142 | 4.9 | NDe | – |
C498 | + | – | + | 7 | 18.0 | ND | – |
C499 | + | – | + | 24 | ND | ND | – |
Bullous pemphigoid | |||||||
BP323 | + | – | + | <1 | 0 | 200 | 2/ND |
BP422 | – | – | – | 3855 | 93.4 | 950 | 6/67 |
BP487 | + | – | + | 115 | 6.2 | ND | 3/30 |
BP501 | + | + | + | 34 | 89.2 | ND | 6/48 |
BP502 | + | – | + | 289 | 4.8 | 350 | 4/18 |
BP504 | – | – | – | 90 | 9.4 | 260 | 6/58 |
Other autoimmune | |||||||
C503: urticarial vasculitis | + | – | + | 770 | 0 | 250 | 5/49 |
C508: scabies | – | – | – | 571 | 0 | 10 | 5/ND |
C497: eczematous dermatitis | + | – | + | 1842 | 3.0 | 750 | 5/25 |
C488: papulopustular eczema | – | – | – | 64 | 71.2 | 710 | 5/79 |
mRNA expression was evaluated by RT-PCR after immunomagnetic purification of eosinophils.
reported as IU/ml, normal range ≤100.
expressed as Index Units, positive test ≥19.
reported as BP index/BPDAI as described in the Methods.
Not done.