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. 2014 Sep 25;9(9):e108649. doi: 10.1371/journal.pone.0108649

Figure 5. The majority of expressed transcripts in cKit+ ILCs are for signal transduction and transcription machinery.

Figure 5

(A) Volcano plot depicting all transcripts with those upregulated shown in red (n = 472) and those downregulated shown in blue (n = 2371). (B) Pie chart showing the functional classification of all transcripts identified. Sub-categories of the immunologically relevant genes are listed (B) with a full listing of all the genes classified as immunologically relevant in Table S1. (C) A heat map of the immunologically relevant transcripts of cKit+ ILCs (n = 6) compared to lineage depleted PBMCs (n = 2). (D) Sorted cKit+ ILCs (n = 6) cultured with media alone (closed circles – Unst) or with a cocktail of TLR ligands for TLR5, TLR6, TLR7 and TLR9 (open circles – Stim) for 3 days.