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. 2014 Sep 25;10(9):e1004368. doi: 10.1371/journal.ppat.1004368

Figure 4. Bone marrow transfer restores responsiveness of hematopoietic cells from Tie2-Myd88−/− mice to Klebsiella.

Figure 4

Whole blood (A), alveolar and peritoneal macrophages (B,C) and splenocytes (D) derived from control mice transplanted with control bone marrow (Co+ Co BM, grey bars) and Tie2-Myd88−/− mice transplanted with control bone marrow (Tie2-Myd88−/−+Co BM, white dotted bars) or Tie2-Myd88−/− bone marrow (Tie2-Myd88−/−+Tie2-Myd88−/− BM, white bars). (n = 2–3 per group) were in vitro stimulated with LPS derived from Klebsiella pneumoniae (1 µg/ml) or heat killed K. pneumoniae in two concentrations (2×105 CFU/ml or 2×107/ml) for 20 hours. Data are expressed as mean (SE). * p<0.05, ** p<0.01. ND = not determined.