Table 1. Inflammatory response in LysM-MyD88−/− and Tie2-MyD88−/− during K. pneumonia pulmonary tract infection.
| Co | LysM-MyD88−/− | Tie2-MyD88−/− | |
| Lung | |||
| TNF-α | 2632 (295) | 2181 (204) | 1610 (159)** |
| IL-1β | 3523 (410) | 2989 (341) | 2559 (350) |
| IL-6 | 3417 (587) | 5112 (697) | 4798 (1666) |
| IL-10 | bd | bd | bd |
| CXCL-1 | 3502 (855) | 5083 (1091) | 5675 (1479) |
| CXCL-2 | 28270 (4621) | 37871 (6138) | 27254 (8982) |
| Plasma | |||
| TNF-α | 12 (4) | 85 (41) | 55 (20)* |
| IL-6 | 240 (47) | 2364 (1251)* | 783 (96)** |
| IL-10 | bd | bd | bd |
| CCL-2 | 468 (330) | 141 (48) | 1297 (428)* |
Control, LysM-MyD88−/− and Tie2-MyD88−/− mice were inoculated with ∼6×103 CFU K. pneumoniae and sacrificed 24 hours later. Homogenates were prepared from right lungs. Cytokine and chemokine levels are presented in pg/ml lung homogenate or plasma. Data are mean (SE) of 5–8 mice per group.
* p<0.05,
** p<0.01 vs control mice.
Bd = below detection.