Table 4. Significative genotype frequencies and susceptibility to leptospirosis.

Gene: dbSNP	Genotypic frequencies				Association analysis
	Cases		Controls		Cases vs controls
	N = 97 (%)		N = 470 (%)		OR	(95% CI)	p-value
IL1β: rs16944
GG	54	(55.7)	206	(43.8)	1.6	(1.01–2.56)	0.044
AG	34	(36.1)	194	(41.1)	0.8	(0.47–1.24)	0.306
AA	9	(9.3)	70	(15.1)	0.6	(0.262–1.27)	0.196
IL12RB1: rs401502
CC	33	(34.0)	190	(40.4)	0.8	(0.47–1.23)	0.288
CG	62	(63.9)	219	(46.6)	2.0	(1.26–3.27)	0.003
GG	2	(2.1)	61	(13.0)	0.1	(0.02–0.60)	0.003
CISH: rs414171
TT	2	(2.1)	6	(1.3)	1.6	(0.22–9.08)	0.901
TA	32	(33.0)	103	(21.9)	1.8	(1.06–2.90)	0.028
AA	63	(65.0)	361	(76.8)	0.6	(0.34–0.92)	0.020
CISH: rs622502
CC	1	(1.0)	4	(0.9)	1.2	(0.05–11.65)	1.000
CG	30	(30.9)	92	(19.6)	1.8	(1.10–3.08)	0.019
GG	66	(68.0)	374	(79.6)	0.5	(0.33–0.91)	0.019

Bold refers to the significant association.