eTable.

Univariate Analysis of Psychological, Clinical and Demographic Factors for Associations with Reduced Health-related Quality of Life in Adults with Strabismus.

Factors included in univariate analysis	Adult Strabismus-20 HRQOL questionnaire domains
	Self-Perception	Interactions	Reading Function	General Function
CESD-R score	P=0.13	P=0.028	P<0.0001	P=0.0003
DS-14 (Type D yes / no)	P=0.11	P=0.020	P=0.51	P=0.19
Diplopia Questionnaire score	P=0.94	P=0.39	P<0.0001	P<0.0001
Horizontal deviation*	P=0.17	P=0.19	P=0.39	P=0.82
Vertical deviation**	P=0.18	P=0.18	P=0.68	P=0.85
Magnitude of deviation†	P<0.0001	P=0.0009	P=0.84	P=0.029
Best eye visual acuity	P=0.53	P=0.65	P=0.31	P=0.040
Visually obtrusive co-morbidity (yes / no)	P=0.27	P=0.29	P=0.96	P=0.092
Age at assessment	P<0.0001	P=0.0002	P=0.039	P=0.0067
Age at onset	P<0.0001	P=0.0018	P=0.88	P=0.94
Sex	P=0.013	P=0.22	P=0.59	P=0.20

Factors with a P value of <0.1 were considered significant and included in multivariate analysis (indicated in bold type).

CESD-R = Center for Epidemiologic Studies Depression Scale – Revised; DS-14 – Distressed personality questionnaire

^*For horizontal deviations patients were classified as esotropia versus not esotropia based on largest magnitude of esotropia, exotropia or vertical deviation measured by simultaneous prism cover test (SPCT) in primary position at distance or near

^** For vertical deviations patients were classified as vertical versus not vertical based on largest magnitude of vertical deviation, measured by SPCT in primary position at distance or near

^†For uniplanar deviations, magnitude was based on largest of distance or near primary position SPCT measurements. For combined horizontal and vertical deviations, magnitude was based on the combined vector.