Table 7.
Comparing PD patient types: group means, standard deviations and p values for select clinical measures and iTUG and iSway disease severity variables.
| PD de-novo (N=15) | PD stable (N=69) | PD fluctuator (N=51) | F* | p-val* | F** | p-val** | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Measure | Mean | SD | Mean | SD | Mean | SD | |||||
| Age | 62.73 | 8.14 | 64.19 | 11.06 | 64.12 | 8.70 | 0.14 | 0.871 | 0.35 | 0.704 | |
| MDS-UPDRS part III | 24.20 | 11.41 | 23.14 | 10.22 | 30.61 | 15.06 | 5.51 | 0.005 | |||
| MDS-UPDRS part III PIGD subscore | 2.00 | 1.51 | 1.71 | 1.65 | 3.24 | 3.11 | 6.60 | 0.002 | 1.84 | 0.164 | |
| iTUG | Gait: Stride Length [CoV] | 0.02 | 0.01 | 0.02 | 0.01 | 0.03 | 0.03 | 4.87 | 0.009 | 1.96 | 0.144 |
| Gait: Stride Length [Mean] | 80.62 | 6.90 | 78.28 | 7.67 | 76.06 | 11.62 | 1.66 | 0.193 | 0.64 | 0.530 | |
| Turn To Sit: Duration | 3.98 | 0.66 | 4.17 | 0.77 | 4.36 | 1.12 | 1.21 | 0.301 | 0.47 | 0.628 | |
| Gait: RoM Knee [Mean] | 55.06 | 5.08 | 53.89 | 5.26 | 52.42 | 5.49 | 1.88 | 0.156 | 0.62 | 0.539 | |
| Gait: Stride Velocity [Mean] | 72.32 | 7.03 | 72.34 | 8.51 | 69.79 | 11.81 | 1.07 | 0.345 | 0.02 | 0.977 | |
| Gait: RoM Shank L [Mean] | 75.52 | 6.99 | 73.72 | 9.95 | 71.52 | 10.82 | 1.20 | 0.305 | 0.34 | 0.715 | |
| Gait: Stride Velocity [CoV] | 0.03 | 0.01 | 0.04 | 0.02 | 0.05 | 0.03 | 2.49 | 0.087 | 0.72 | 0.488 | |
| Total Duration | 16.42 | 1.79 | 16.78 | 3.29 | 18.06 | 6.40 | 1.38 | 0.256 | 0.17 | 0.844 | |
| Gait: RoM Shank [CoV] | 0.02 | 0.01 | 0.02 | 0.01 | 0.03 | 0.03 | 3.26 | 0.042 | 1.17 | 0.314 | |
| Gait: RoM Knee L [Mean] | 57.21 | 5.03 | 56.28 | 5.96 | 55.26 | 5.16 | 0.89 | 0.412 | 0.27 | 0.767 | |
| iSway | Centroidal frequency (AP) | 0.54 | 0.21 | 0.57 | 0.18 | 0.68 | 0.31 | 3.57 | 0.031 | 1.41 | 0.249 |
| Path length | 5.37 | 1.78 | 6.58 | 7.80 | 12.57 | 14.77 | 5.42 | 0.006 | 2.97 | 0.055 | |
| Jerk (ML) | 0.00 | 0.00 | 0.01 | 0.04 | 0.04 | 0.13 | 2.77 | 0.067 | 0.97 | 0.383 | |
| Mean frequency | 0.45 | 0.09 | 0.50 | 0.14 | 0.65 | 0.41 | 5.34 | 0.006 | 2.77 | 0.066 | |
| Median frequency (AP) | 0.33 | 0.07 | 0.33 | 0.07 | 0.42 | 0.35 | 2.58 | 0.080 | 0.79 | 0.454 | |
| Normalized jerk | 4.61 | 0.70 | 4.96 | 1.07 | 5.85 | 3.29 | 3.20 | 0.044 | 1.33 | 0.268 | |
| Mean distance (ML) | 0.02 | 0.01 | 0.02 | 0.03 | 0.04 | 0.04 | 4.30 | 0.016 | 2.39 | 0.095 | |
| Path length (AP) | 4.10 | 1.63 | 4.75 | 5.77 | 8.27 | 8.87 | 4.49 | 0.013 | 2.73 | 0.069 | |
| Centroidal frequency | 0.67 | 0.18 | 0.72 | 0.19 | 0.82 | 0.27 | 4.55 | 0.012 | 2.62 | 0.076 | |
| Frequency dispersion (ML) | 0.74 | 0.10 | 0.70 | 0.10 | 0.69 | 0.12 | 1.69 | 0.189 | 1.22 | 0.299 | |
*
ANOVA (comparing means of the 3 groups)
**
ANCOVA (comparing means of the 3 groups while controlling for disease severity as measured by MDS-UPDRS3 part III)