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. 2014 Sep 25;10(9):e1004380. doi: 10.1371/journal.ppat.1004380

Figure 7. Expression levels of perforin and granzyme B in CD8 T-cell subsets defined by the expression of 2B4, CD160 and PD-1.

Figure 7

CD8 T-cell responses were analyzed within six CD8 T-cell subsets defined by 2B4, CD160 and/or PD-1 expression. (A) Representative flow cytometric profiles of CD8 T cells expressing perforin and/or granzyme B ex vivo. (B) Frequencies of CD8 T cells expressing perforin and granzyme B. (C) Representative flow cytometric profiles of differentiated CD8 T-cell subsets defined by the CCR7 and CD45RA expressing perforin, 2B4, CD160 and PD-1. (D) Cumulative analyses (n = 10) representing the expression of perforin differentiated CD8 T-cell subsets in function of CD160 expression. Red bars correspond to mean ± SEM. Red stars indicate statistical significance (P<0.05). NS: not significant. Statistical significance (P values) in panels B and D were obtained using One-way ANOVA (Kruskal-Wallis test) followed by a paired Student's t-test.