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Macaques were treated with 2 mL of MZC (n = 9) or CG gel (n = 8) intravaginally daily for 14d. Vaginal biopsies were collected from all macaques at the baseline (4 wks before Depo treatment) and 24 h after the last gel exposure to determine PD of MZC in tissues. Ectocervical biopsies were collected from 5 macaques in both groups. VF was collected just before collection of biopsies to assess PK of MIV-150.
