Table 3. Univariate analysis of clinicopathological factors, serum biochemical index and response rate, PFS and OS in 316 patients.

Parameter			Response rate							PFS							OS
			OR		95% CI		P			HR		95% CI		P			HR		95% CI		P
Age
<65			1							1							1
≥65			0.649		0.285-1.476		0.302			1.263		0.948-1.681		0.11			1.553		1.165-2.070		0.003
Gender
Female			1							1							1
Male			1.119		0.498-2.513		0.786			1.408		1.018-1.947		0.039			1.566		1.131-2.169		0.007
Smoke status
Never			1							1							1
Ever			0.924		0.434-1.967		0.838			1.317		0.979-1.770		0.069			1.603		1.189-2.161		0.002
Histology
Non-squa			1							1							1
Squamous			0.547		0.219-1.366		0.197			1.135		0.846-1.524		0.398			1.313		0.978-1.763		0.07
Differentiation
Non-poor			1							1							1
Poor			3.137		1.029-9.565		0.044			1.296		0.908-1.850		0.153			1.232		0.863-1.759		0.251
TNM stage
III			1							1							1
IV			2.296		0.879-5.997		0.09			1.718		1.207-2.446		0.003			1.63		1.145-2.321		0.007
Tumor stage
T1			1							1							1
T2			1		0.269-3.724		1			0.902		0.547-1.489		0.688			1.057		0.641-1.743		0.828
T3			4		0.733-21.838		0.109			2.128		1.202-3.767		0.01			2.957		1.666-5.248		0
T4			1.792		0.543-5.919		0.338			1.313		0.813-2.121		0.265			1.351		0.836-2.181		0.219
Node stage
N0			1							1							1
N1			2		0.334-11.969		0.448			1.953		1.072-3.557		0.029			2.143		1.174-3.909		0.013
N2			1.406		0.366-5.399		0.619			1.495		0.924-2.417		0.101			1.626		1.005-2.631		0.048
N3			3.111		0.781-12.384		0.108			1.89		1.116-3.200		0.018			1.764		1.042-2.986		0.035
Metastasis stage
M0			1							1							1
M1a			1.705		0.514-5.656		0.384			1.198		0.773-1.858		0.419			1.195		0.770-1.855		0.426
M1b			2.58		0.955-6.969		0.061			2.061		1.428-2.976		0			1.887		1.308-2.721		0.001
Metastasis number
None	1							1										1
Single	1.77	0.651-4.810		0.263				1.557			1.082-2.240		0.017					1.502		1.044-2.161		0.028
Multiple	5.278	1.586-17.564		0.007				2.648			1.669-4.201		0					2.283		1.443-3.612		0
Metastasis symptom
Never	1							1										1
Ever	0.692	0.243-1.975		0.492				1.157			0.783-1.711		0.464					1.209		0.817-1.787		0.342
ECOG PS
≤1	1							1										1
>1	1.16	0.468-2.876		0.748				1.657			1.216-2.257		0.001					1.654		1.213-2.256		0.001
Albumin
>35	1							1										1
≤35	0.141	0.012-1.604		0.114				2.458			1.442-4.192		0.001					2.75		1.614-4.684		0
Globulin
≤27	1							1										1
>27	0.65	0.279-1.517		0.319				1.266			0.948-1.691		0.109					1.471		1.101-1.965		0.009
GAR
≤0.58	1							1										1
>0.58	0.814	0.382-1.735		0.594				1.664			1.233-2.247		0.001					1.959		1.449-2.649		0

OR, odd ratio; HR, hazard ratio; CI, confidence interval; TNM stage, Tumor-Node-Metastasis stage; ECOG PS, the Eastern Cooperative Oncology Group Performance Status Scale; GAR, globulin albumin ratio; PFS, progression-free survival; OS, overall survival.