Figure 1.

Fibroblast growth factor receptor (FGFR)4 deficiency reduced mammary tumor incidence. The age-matched C57BL/6 J KO-Tg and Tg mice as indicated were examined for the presence of palpable breast tumor foci that were further confirmed by pathological examination on tissue sections under microscope. The incidence rate of breast tumor was determined monthly as the percentage of the whole population in each group (Tg, 218 mice; KO-Tg, 206 mice). Experimental data from three cohorts are expressed as mean ± SD; P <0.05. KO, FGFR4 knockout; Tg, MMTV-TGFα transgenic mouse.