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Fibroblast growth factor receptor (FGFR)4 deficiency increased the survival of mice with breast tumor. Life spans were scored in days as described in Methods. We monitored 245 Tg and 216 KO-Tg mice. The rates of overall (A) and post breast tumor diagnosis survival (B) in both the FGFR4-deficient and WT mice with TGFα overexpression were determined by Kaplan-Meier analysis. Tg, MMTV-TGFα transgenic; KO, FGFR4 knockout; WT, wild-type; TGFα, transforming growth factor alpha.
