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. 2014 Nov 26;6(5):511–525. doi: 10.4252/wjsc.v6.i5.511

Figure 3.

Figure 3

Data from Giudice et al[151] showing the impact of histone deacetylases inhibitor on the population of CICs. A: Fluorescence-activated cell sorting of ALDH+ cells demonstrates that HNSCC cell lines have a high number CICs, and that administration of TSA reduced total number of ALDH+ cells; B: HDACi (TSA) disrupts tumor spheres as depicted in representative images of tumor spheres and by quantification of spheres (HN6 bP < 0.01, HN13 aP < 0.05). TSA: Trichostatin A; ALDH: Aldehyde dehydrogenase; SCC: Side scatter of light; HDACi: Histone deacteylases inhibitors; HNSCC: Head and neck squamous cell carcinoma.