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. 2014 Apr 12;63(5):1465–1474. doi: 10.2337/db13-1543

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© 2014 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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T2-weighted MRI in NOD mice. A: Representative 3D T2*-weighted MRI of a 5-week-old NOD mouse shows pancreatic area used for analysis. B: The ΔT2 of the pancreata of 15-week-old mice injected with MN-Ex10-Cy5.5 was significantly decreased (*P < 0.05) compared with that of 5-week-old NOD mice. C: Anti–GLP-1R immunostaining of the pancreata from prediabetic and diabetic NOD mice injected with MN-Ex-Cy5.5 or control probes. Cy5.5 (red), GLP-1R (green), DAPI nuclear stain (blue); magnification bar = 20 μm. D: Anti-insulin immunostaining of the pancreata from prediabetic and diabetic NOD mice injected with MN-Ex-Cy5.5 or control probes. Cy5.5 (red), insulin (green), and DAPI nuclear stain (blue); magnification bar = 20 μm. wks, weeks.