Table 2.
Multivariable association between measures of kidney function and risk of incident renal cancer (overall and by type)
| eGFR (ml/min per 1.73 m2) | Cancer Cases Number and Adjusted HR (95% CI)a | |||||
|---|---|---|---|---|---|---|
| Any Renal Cell Carcinomab | Clear Cell Renal Carcinomac | Nonclear Cell Renal Carcinomac | ||||
| N | HR (95% CI) | N | HR (95% CI) | N | HR (95% CI) | |
| 90–150 | 241 | 1.08 (0.93 to 1.26) | 116 | 1.12 (0.9 to 1.39) | 40 | 1.37 (0.93 to 2.00) |
| 60–89 | 826 | Reference | 383 | Reference | 117 | Reference |
| 45–59 | 395 | 1.39 (1.22 to 1.58) | 165 | 1.29 (1.06 to 1.58) | 52 | 1.24 (0.87 to 1.76) |
| 30–44 | 196 | 1.81 (1.51 to 2.17) | 80 | 1.71 (1.29 to 2.26) | 25 | 1.55 (0.96 to 2.49) |
| <30 | 92 | 2.28 (1.78 to 2.92) | 28 | 1.68 (1.09 to 2.58) | 6 | 0.92 (0.38 to 2.21) |
HR, hazard ratio; 95% CI, 95% confidence interval.
a
Final models adjusted for age, sex, race, income, education, smoking, body mass index, prior health care use, proteinuria, hematuria, imaging use, specific comorbidities, and prescription drug use as listed in Table 1.
b
List of histology codes: 80003, 80103, 80503, 81403, 82113, 82553, 82603, 83103, 83123, 83163, 83173, 83183, 83193, 83203, and 83233.
c
Histology codes: clear cell carcinomas, 83103; nonclear cell carcinomas, 80503, 82603, 83163, 83173, 83183, 83193, and 83203.