Table 1.

Humoral data from rats stratified for experimental groups and time points

Variable	Control Early	Adenine Nephropathy Early	5/6 Nephrectomy Early	Control Late	Adenine Nephropathy Late	5/6 Nephrectomy Late
S-creatininea (μmol/L)	23±1.1	104±18.4b,c	72±19.8b,c	26±0.9	107±23.6b	86±17.8b
S-ureaa (mmol/L)	6.4±0.4	13±1.2b	17.5±3b	6.9±0.6	17.5±3b	19±4.7b
S-phosphatea (mmol/L)	2.4±0.09	3.4±0.8d	3.8±0.47e	2.3±0.07	3.1±0.6c,f	4.2±0.9b,c
Creatinine clearanceg (ml/min per kg)	8.9±0.44	3.5±0.68b	2.9±0.5b	8.7±0.52	2.7±0.31b	2.2±0.49b

Values are expressed as the mean±SD.

^aAverage over experiment, weekly determination.

^bP<0.001 versus control.

^cP<0.05 between adenine nephrectomy and 5/6 nephrectomy.

^dP<0.05 versus control.

^eP<0.01 versus control (one way ANOVA, post hoc Scheffe test).

^fP=NS versus control.

^gAverage over experiment, determination every second week.