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. 2014 Apr 3;25(10):2201–2212. doi: 10.1681/ASN.2013070735

Figure 7.

Figure 7.

Small molecule Hh inhibitors reduce cystogenic potential of cultured jck/jck and Pkd1m1Bei/m1Bei kidneys. (A) E13.5 jck/jck kidneys and (B) E14.5 Pkd1m1Bei/Pkd1m1Bei were cultured in the presence of 100 μM 8-bromo-cAMP, in combination with 10 μM Gant61, 5 μM or 10 μM Sant2 (for jck/jck or Pkd1m1Bei/Pkd1m1Bei kidneys, respectively), or control DMSO for 4 days. Graphs represent quantification of kidney images following 4-day culture. Bars represent mean±SEM; n=3 wt, n=9 jck/+, and n=5 jck/jck kidneys from 3 experiments for Gant61; n=5 wt, n=9 jck/+, and n=8 jck/jck kidneys from 4 experiments for Sant2; n=6 wt, n=12 Pkd1m1Bei/+, and n=9 Pkd1m1Bei/Pkd1m1Bei from 4 experiments for Gant61; n=7 wt, n=10 Pkd1m1Bei/+ and n=6 Pkd1m1Bei/Pkd1m1Bei from 4 experiments for Sant2. *P<0.05; **P<0.005; ***P<0.0005; ****P<0.00005.