Figure 4.

SYK inhibition abrogates glomerular inflammatory cell infiltration in experimental anti-GBM disease. (A) Glomerular macrophages were identified using anti–ED-1 mAb and quantified per GCS. Fostamatinib-treated animals had 95% reduction in glomerular macrophage infiltration at day 36. (B) Representative photomicrographs showing ED-1 staining in vehicle- and fostamatinib-treated animals at day 36. (C) Fostamatinib-treated animals also had 95% reduction in glomerular CD8⁺ cells at day 36. (D) Representative CD8 staining for vehicle- and fostamatinib-treated animals at day 36. Original magnification for all images with hematoxylin counterstain, ×400. Animals: n=8/group. Data are reported as median per group±interquartile range. **P<0.01; ***P<0.001.