Figure 7.

SYK inhibition has additional effects in EAG independent of effects on autoantibody production. (A) Incubation with R406, the active metabolite of fostamatinib, reduced spontaneous proinflammatory cytokine production by nephritic glomeruli ex vivo in a dose-dependent manner. Results from four biologic replicate experiments are shown, with data from each experiment normalized to vehicle group measurements. (B) R406 inhibited the production of proinflammatory cytokines by primary BMDMs in vitro after stimulation with heat-aggregated IgG (aIgG). Replicate results (×3) from one of at least two biologic replicate experiments are shown. Data are reported as median per group±interquartile range. *P<0.05; **P<0.01.