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. 2014 Apr 3;25(10):2366–2375. doi: 10.1681/ASN.2013101085

Table 2.

Univariate and multivariate regression model identifies association of genotype and biochemical variables with renal calcifications

Variable Unit Renal Calcifications
Unadjusted, All Adjusted, All (for Genotype or Sex/Agea) Unadjusted, Comp/Hom Only
N OR 95% CI P Value N Adjusted OR 95% CI P Value N OR 95% CI P Value
Lower Upper Lower Upper Lower Upper
NPT2c mutation Alleles 122 3.90 1.31 11.63 0.02 89 12.2a 2.04 72.3 <0.01
Women Yes 133 0.83 0.41 1.69 0.61 43 0.58 0.14 2.36 0.45
Age Year 94 1.00 0.97 1.03 0.86 41 1.02 0.96 1.10 0.51
Serum 25(OH)D 50 nmol/L 71 1.46 0.52 4.12 0.47 71 2.23 0.85 5.87 0.11 33 2.72 0.70 10.59 0.15
Serum calcium 1 SD 79 0.91 0.60 1.37 0.64 77 0.86 0.57 1.31 0.49 33 0.95 0.62 1.46 0.82
Serum phosphate 1 SD 100 0.75 0.59 0.96 0.02 98 0.98 0.71 1.37 0.92 42 0.93 0.58 1.47 0.75
Serum intact PTH 10% UL 78 0.80 0.59 1.07 0.13 76 0.97 0.71 1.32 0.83 32 0.92 0.61 1.40 0.71
Serum 1,25(OH)2D 50 pmol/L 86 1.22 1.05 1.41 <0.01 85 1.09 0.96 1.25 0.19 39 1.11 0.97 1.26 0.12
uCa/uCrea 50% UL 88 1.39 0.94 2.05 0.10 85 0.92 0.59 1.45 0.73 38 0.87 0.51 1.45 0.58
TRP (%) 10% 68 0.41 0.23 0.72 0.002 66 0.54 0.31 0.92 0.02 27 0.65 0.38 1.10 0.11
Serum ALP 1 SD 73 1.04 0.95 1.15 0.40 72 0.97 0.90 1.04 0.37 29 0.96 0.89 1.04 0.30
Bone disease Yes 133 2.90 1.24 6.77 0.01 122 1.42 0.39 5.22 0.60 43 0.43 0.13 1.40 0.16

A univariate logistic regression model (GENMOD; SAS Institute, Inc.) was applied to estimate the unadjusted odds ratios (ORs) and those ORs were further adjusted for genotype (adjusted OR) as well as sex and age using a multivariate logistic regression model. An OR of one indicates that renal or bone involvement is equally likely to occur in individuals with a given variable. An OR greater than one indicates that renal or bone involvement is more likely to occur in individuals with high measurements of a given variable at the indicated units. An OR less than one indicates that renal or bone involvement is less likely to occur with high measurements of a given variable at the indicated units. 95% CI, 95% confidence interval.

a

Odds ratios were further adjusted for sex and age by using a multivariate logistic regression model.