Table 3.

Univariate and multivariate regression model identifies association of genotype and biochemical variables with bone disease

Variable	Unit	Bone Disease
		Unadjusted					Adjusted, All (for Genotype or Sex and Agea)					Unadjusted, Comp/Hom Only
		N	OR	95% CI		P Value	N	Adjusted OR	95% CI		P Value	N	OR	95% CI		P Value
				Lower	Upper				Lower	Upper				Lower	Upper
NPT2c mutation	Alleles	122	20.8	7.84	55.09	<0.001	89	33.9a	9.52	120.9	<0.001
Women	Yes	133	0.71	0.33	1.55	0.39						43	0.43	0.08	2.41	0.34
Age	Year	94	0.96	0.92	0.99	0.02						41	1.02	0.97	1.08	0.45
Serum 25(OH)D	50 nmol/L	71	0.74	0.31	1.79	0.51	71	1.18	0.40	3.49	0.77	33	1.22	0.22	6.79	0.82
Serum calcium	1 SD	79	1.32	0.80	2.18	0.28	77	1.41	0.87	2.28	0.16	33	1.19	0.75	1.88	0.45
Serum phosphate	1 SD	100	0.39	0.24	0.63	<0.001	98	0.50	0.30	0.83	<0.01	42	0.45	0.19	1.03	0.06
Serum intact PTH	10% UL	78	0.73	0.62	0.87	<0.001	76	0.94	0.78	1.14	0.51	32	1.16	0.71	1.88	0.56
Serum 1,25(OH)2D	50 pmol/L	86	1.62	1.20	2.20	0.002	85	1.32	1.04	1.69	0.02	39	1.43	1.01	2.02	0.04
uCa/uCrea	50% UL	88	2.62	1.36	5.05	0.004	85	1.45	0.66	3.21	0.35	38	1.38	0.51	3.72	0.52
TRP(%)	10%	68	0.23	0.13	0.40	<0.001	66	0.21	0.08	0.56	0.002	27	0.02	0.00	0.94	0.05
Serum ALP	1 SD	73	2.46	1.73	3.50	<0.001	72	2.00	1.24	3.20	0.004	29	1.45	1.04	2.02	0.03
Renal calcifications	Yes	133	2.90	1.24	6.77	0.01	122	1.39	0.36	5.33	0.63	43	0.43	0.13	1.40	0.16

A univariate logistic regression model (GENMOD; SAS Institute, Inc.) was applied to estimate the unadjusted odds ratios (ORs) and those ORs were further adjusted for genotype (adjusted OR) as well as sex and age using a multivariate logistic regression model. An OR of one indicates that renal or bone involvement is equally likely to occur in individuals with a given variable. An OR greater than one indicates that renal or bone involvement is more likely to occur in individuals with high measurements of a given variable at the indicated units. An OR less than one indicates that renal or bone involvement is less likely to occur with high measurements of a given variable at the indicated units. 95% CI, 95% confidence interval.

^aOdds ratios were further adjusted for sex and age by using a multivariate logistic regression model.