Table 2.
Unadjusted incidence rates and IRRs for cancer type, by PKD status
| Cancer Type | PKD Recipients | Non-PKD Recipients | IRR (95% CI) | ||
|---|---|---|---|---|---|
| Count (n) | Incidence Ratea | Count (n) | Incidence Ratea | ||
| Lip | 13 | 25.8 | 74 | 15.5 | 1.66 (0.88 to 2.89) |
| Salivary gland | 7 | 13.9 | 30 | 6.3 | 2.20 (0.89 to 4.73) |
| Oropharynx | 7 | 13.9 | 39 | 8.2 | 1.70 (0.69 to 3.56) |
| Other oral cavity and pharynx | 5 | 9.9 | 75 | 15.7 | 0.63 (0.22 to 1.41) |
| Nasopharynxb | 0 | 0 | 7 | 1.5 | 0 |
| Esophagus | 5 | 9.9 | 47 | 9.9 | 1.00 (0.35 to 2.29) |
| Stomach | 8 | 15.9 | 91 | 19.1 | 0.83 (0.37 to 1.60) |
| Small intestine | 2 | 4.0 | 19 | 4.0 | 0.99 (0.16 to 3.42) |
| Colon and rectum | 25 | 49.6 | 328 | 68.9 | 0.72 (0.47 to 1.06) |
| Anus | 3 | 5.9 | 51 | 10.7 | 0.56 (0.14 to 1.51) |
| Liver | 4 | 7.9 | 51 | 10.7 | 0.74 (0.22 to 1.81) |
| Intrahepatic bile duct | 2 | 4.0 | 3 | 0.6 | 6.30 (0.83 to 37.99) |
| Gallbladderb | 0 | 0 | 7 | 1.5 | 0 |
| Other biliary | 4 | 7.9 | 11 | 2.3 | 3.43 (0.95 to 10.04) |
| Pancreas | 14 | 27.8 | 84 | 17.6 | 1.57 (0.86 to 2.68) |
| Larynx | 2 | 4.0 | 45 | 9.4 | 0.42 (0.07 to 1.36) |
| Lung | 69 | 136.8 | 582 | 122.2 | 1.12 (0.86 to 1.43) |
| Bones and jointsb | 0 | 0 | 11 | 2.3 | 0 |
| Soft tissue including heart | 8 | 15.9 | 32 | 6.7 | 2.36 (1.01 to 4.87) |
| Melanoma | 48 | 95.2 | 225 | 47.2 | 2.01 (1.46 to 2.72) |
| Other nonepithelial skin | 20 | 39.7 | 107 | 22.5 | 1.77 (1.06 to 2.78) |
| Breast | 37 | 73.4 | 299 | 62.8 | 1.17 (0.82 to 1.62) |
| Cervixb | 0 | 0 | 27 | 13.9 | 0 |
| Uterus | 12 | 53.2 | 60 | 30.8 | 1.89 (0.97 to 3.38) |
| Ovary | 4 | 17.7 | 26 | 13.3 | 1.45 (0.43 to 3.73) |
| Vaginab | 0 | 0 | 8 | 4.1 | 0 |
| Vulva | 6 | 26.6 | 34 | 17.5 | 1.67 (0.63 to 3.69) |
| Prostate | 74 | 265.6 | 555 | 197.2 | 1.26 (0.98 to 1.59) |
| Testis | 5 | 17.9 | 26 | 9.2 | 1.82 (0.61 to 4.35) |
| Penisb | 0 | 0 | 15 | 5.3 | 0 |
| Bladder | 13 | 25.8 | 142 | 29.8 | 0.86 (0.47 to 1.47) |
| Kidney | 49 | 97.2 | 610 | 128.1 | 0.76 (0.56 to 1.00) |
| RCCc | 45 | 89.2 | 505 | 106.0 | 0.84 (0.61 to 1.13) |
| Renal pelvis | 1 | 2.0 | 15 | 3.1 | 0.63 (0.03 to 3.11) |
| Eye and orbit | 4 | 7.9 | 12 | 2.5 | 3.15 (0.88 to 9.04) |
| Brain | 5 | 9.9 | 29 | 6.1 | 1.63 (0.55 to 3.85) |
| Thyroid | 16 | 31.7 | 168 | 35.3 | 0.90 (0.52 to 1.45) |
| Hodgkin lymphoma | 5 | 9.9 | 49 | 10.3 | 0.96 (0.33 to 2.19) |
| Non-Hodgkin lymphoma | 74 | 146.8 | 672 | 141.1 | 1.04 (0.81 to 1.31) |
| Plasma cell neoplasms | 8 | 15.9 | 73 | 15.3 | 1.03 (0.46 to 2.02) |
| Acute lymphocytic leukemia | 1 | 2.0 | 8 | 1.7 | 1.18 (0.06 to 6.44) |
| Chronic lymphocytic leukemia | 1 | 2.0 | 14 | 2.9 | 0.67 (0.04 to 3.36) |
| Acute myeloid leukemia | 7 | 13.9 | 36 | 7.6 | 1.84 (0.75 to 3.88) |
| Chronic myeloid leukemia | 3 | 5.9 | 20 | 4.2 | 1.42 (0.33 to 4.13) |
| Acute monocytic leukemiab | 0 | 0 | 1 | 0.2 | 0 |
| Other acute leukemiab | 0 | 0 | 4 | 0.8 | 0 |
| Mesothelioma | 1 | 2.0 | 12 | 2.5 | 0.79 (0.04 to 3.99) |
| Kaposi sarcoma | 6 | 11.9 | 73 | 15.3 | 0.78 (0.30 to 1.64) |
| Miscellaneous | 37 | 73.4 | 327 | 68.7 | 1.07 (0.75 to 1.48) |
| Tumors of poorly specified morphology | 7 | 13.9 | 96 | 20.2 | 0.69 (0.29 to 1.38) |
| All cancers, combined | 622 | 1233.6 | 5330 | 1119.1 | 1.10 (1.01 to 1.20) |
| All cancers excluding kidney, melanoma, and nonepithelial skin | 505 | 1001.6 | 4388 | 921.3 | 1.09 (0.99 to 1.19) |
a
Incidence rate is per 100,000 person-years.
b
Because there were no cases among PKD recipients, the Poisson regression model did not converge.
c
RCCs are shown separately in the table, but because all were located in the kidney, they do not contribute to the total.