Table 3.
Determinants of kidney transplant graft outcome after acute ABMR: univariate analysis
| Parameters | HR | 95% CI | P Value |
|---|---|---|---|
| Clinical parameters | |||
| Recipient age, yr | 1.02 | 0.98 to 1.06 | 0.31 |
| Cold ischemia time, min | 1.01 | 0.97 to 1.05 | 0.71 |
| Donor age, yr | |||
| <60 | 1 | — | |
| ≥60 | 3.58 | 1.45 to 8.87 | 0.01 |
| Proteinuria at biopsy, g/L | |||
| <0.15 | 1 | — | |
| ≥0.15 | 1.52 | 0.82 to 2.81 | 0.18 |
| Immunologic parameters | |||
| Immunodominant DSA MFI at the time of rejection | 1.00 | 0.99 to 1.00 | 0.42 |
| Functional parameters | |||
| eGFRa at 1 yr | |||
| eGFR≥30 | 1 | — | |
| eGFR<30 | 3.04 | 1.28 to 7.22 | 0.01 |
| Histologic parameters | |||
| Arterial fibrous intimal thickening score | 0.96 | 0.64 to 1.44 | 0.86 |
| cg score | 1.85 | 1.18 to 2.90 | 0.01 |
| Interstitial fibrosis/tubular atrophy score | 1.84 | 1.21 to 2.78 | 0.01 |
| Interstitial inflammation score | 0.75 | 0.45 to 1.24 | 0.26 |
| Tubulitis score | 0.66 | 0.39 to 1.11 | 0.12 |
| v scoreb | 1.20 | 0.45 to 3.08 | 0.13 |
| g score | 1.45 | 0.89 to 2.35 | 0.13 |
| ptc score | 1.99 | 0.97 to 4.07 | 0.06 |
| C4d Banff score | 1.47 | 1.03 to 2.08 | 0.03 |
| Humoral histologic scorec | 1.36 | 1.08 to 1.71 | 0.01 |
| Molecular parameters | |||
| ABMR Molecular Score | 8.82 | 1.82 to 42.73 | 0.01 |
| Endothelial DSA-selective transcripts | 2.94 | 1.00 to 8.69 | 0.05 |
| NK transcripts | 1.61 | 0.81 to 3.22 | 0.18 |
| T-cell transcripts | 0.93 | 0.50 to 1.73 | 0.83 |
| AKI score | 1.17 | 0.63 to 2.18 | 0.61 |
a
eGFR using the Modification of Diet in Renal Disease formula.
b
Note that all ABMR episodes with v lesions in the present study were treated by antibody-targeting strategies.2
c
Humoral histologic score defined by g+ptc+v+cg+C4d Banff scores.