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(A) illustrates the reversal of BRM acetylation following 3 µM treatment for 72h with (1) Luteolin, (2) Quercetin or (3) Genistein in the H460 or H157 cell lines. (B and C) H460 and H157 demonstrate the induction of BRM-dependent genes by at least 4- to 5-fold in both the H460 and H157 cells that were transduced with scrambled shRNA (control), while these genes were observed to be induced in these same cell lines (P < 0.05) when they were transduced with anti-BRM shRNA (BRM-KD).
