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. 2014 Jun 5;35(10):2214–2223. doi: 10.1093/carcin/bgu126

Fig. 6.

Fig. 6.

ING1b SUMOylation affects ING1b binding to and modulates transcription of ISG15 and DGCR8. (A) ISG15 and DGCR8 mRNA expression was quantified by reverse transcription–qPCR in cells either expressing empty vector, ING1b WT or ING1b E195A. All the gene expression levels were normalized to GAPDH. Results represent differences in ISG15 and DGCR8 relative to ING1b expression ± SD. (*P < 0.05; **P < 0.01; ***P < 0.001; NS, not significant). (B) Binding of ING1b on ISG15 and DGCR8 promoters was analyzed by ChIP. Mouse IgG was used as a negative control. Bar graphs represent fold changes in ING1b on ISG15 and DGCR8 promoter occupancy of cells transfected as in Figure 1A ± SD. (*P < 0.05; **P < 0.01; NS, not significant).