Table 4.
Effect of NeoSTX on hematological parameters in rats at 12 weeks (n = 5 per groups).
| Control | Solvent | NSTX 1 μg/kg | NSTX 3 μg/kg | NSTX 6 μg/kg | |
|---|---|---|---|---|---|
| Hemoglobin (%) | 15.0 ± 2.3 | 15.4 ± 1.7 | 15.8 ± 3.4 | 16.4 ± 2.6 | 15.5 ± 1.9 |
| RBC Count (106/μL) | 9.36 ± 0.30 | 9.40 ± 0.84 | 9.05 ± 0.22 | 9.23 ± 0.13 | 8.42 ± 1.30 |
| Hemotocrite (%) | 52.0 ± 1.4 | 52.9 ± 1.8 | 52.2 ± 2.2 | 52.3 ± 0.6 | 53.1 ± 2.1 |
| MCV (fL) | 55.5 ± 0.5 | 56.0 ± 4.3 | 57.6 ± 1.6 | 56.7 ± 0.6 | 55.1 ±2.3 |
| MCH (pg) | 16.9 ± 0.2 | 17.8 ± 0.3 | 17.1 ± 0.2 | 17.5 ± 0.4 | 17.2 ± 0.5 |
| MCHC (g/dL) | 30.4 ± 0.4 | 32.0 ± 2.6 | 31.4 ± 0.8 | 31.7 ± 0.2 | 32.4 ± 1.2 |
| Platelet count (103/μL) | 1238 ± 360 | 1145 ± 407 | 995 ± 330 | 1050 ± 200 | 1090 ± 180 |
| WBC (103/μL) | 3.9 ± 0.9 | 4.5 ± 2.3 | 5.3 ± 2.3 | 4.8 ± 0.7 | 4.0 ± 0.8 |
| Reticulocyte (%) | 0 | 0 | 0 | 0 | 0 |
| Neutrophils (%) | 12 ± 6 | 5 ± 2 | 7 ± 3 | 4 ± 2 | 7 ± 2 |
| Lynphocytes (%) | 88 ± 6 | 92 ± 2 | 92 ± 3 | 93 ± 3 | 91 ± 4 |
| Eosinophils (%) | 0 | 1 ± 1 | 1 ± 1 | 1 ± 1 | 2 ± 2 |
| Monocytes (%) | 0 | 1 ± 1 | 0 | 2 ± 2 | 0 |
| Basophils (%) | 0 | 0 | 0 | 0 | 0 |