Table 6.
Effect of NeoSTX on serum biochemical parameters at 12 weeks (n = 5 per group). * p < 0.05 vs. control.
| Control | Solvent | NeoSTX 1 μg/kg | NeoSTX 3 μg/kg | NeoSTX 6 μg/kg | |
|---|---|---|---|---|---|
| Glucose (mg/dL) | 326.2 ± 82.4 | 367.8 ± 59.95 | 289.6 ± 45.23 | 303.8 ± 47.21 | 307.8 ± 117.78 |
| Ureic Nitrogen (mg/dL) | 15.5 ± 2.1 | 18.8 ± 1.17 | 17.4 ± 1.85 | 15.6 ± 1.6 | 18.4 ± 1.4 |
| Ureic acid (mg/dL) | 1.02 ± 0.25 | 1.12 ± 0.44 | 0.88 ± 0.44 | 1.04 ± 0.32 | 4.5 ± 4.00 |
| Total Protein (g/dL) | 6.42 ± 0.12 | 6.26 ± 0.36 | 6.46 ± 0.28 | 6.44 ± 0.36 | 6.65 ± 0.37 |
| Albumin (g/dL) | 3.28 ± 0.21 | 3.2 ± 0.16 | 3.28 ± 0.22 | 3.38 ± 0.15 | 3.59 ± 0.24 |
| Total Cholesterol (mg/dL) | 58.2 ± 6.58 | 61.2 ± 5.71 | 72.4 ± 13.66 | 64.8 ± 7.76 | 68.6 ± 5.38 |
| HDL (mg/dL) | 35.4 ± 5.78 | 39.2 ± 3.41 | 46.8 ± 6.23 | 41.2 ± 5.27 | 46.6 ± 8.69 |
| LDL (mg/dL) | 7.72 ± 5.06 | 14.28 ± 16.98 | 9.42 ± 5.63 | 12.76 ± 4.59 | 10.08 ± 5.79 |
| Triglycerides (mg/dL) | 75.8 ± 28.13 | 132.5 ± 107.88 | 107.4 ± 70.43 | 54.2 ± 20.88 | 91.2 ± 40.36 |
| LDH (U/L) | 2383.8 ± 760.51 | 2356.6 ± 1024.64 | 2475.2 ± 528.45 | 2302.6 ± 727.33 | 4015.5 ± 2497.87 |
| Creatinine (mg/dL) | 0.52 ± 0.04 | 0.54 ± 0.05 | 0.54 ± 0.05 | 0.46 ± 0.05 | 0.54 ± 0.08 |
| Total Bilirubin (mg/dL) | 0.11 ± 0.02 | 0.13 ± 0.02 | 0.14 ± 0.02 | 0.13 ± 0.02 | 0.38 ± 0.03 * |
| Direct Bilirubin (mg/dL) | 0.01 ± 0.02 | 0.02 ± 0.04 | 0.03 ± 0.04 | 0.02 ± 0.02 | 0.30 ± 0.07 * |
| Alkaline Phosphatase (U/L) | 206.4 ± 56.57 | 238.2 ± 62.31 | 293.4 ± 30.72 | 292.2 ± 68.38 | 237.4 ± 67.93 |
| GGT (U/L) | 7.2 ± 3.53 | 7.4 ± 0.84 | 7.5 ± 0.87 | 8.2 ± 4.17 | 12.5 ± 2.75 * |
| SGOT (UI/dL) | 91.2 ± 8.45 | 88.6 ± 12.12 | 95.7 ± 10.92 | 81.2 ± 11.07 | 142.8 ± 15.42 * |
| SGPT (UI/dL) | 67.8 ± 6.96 | 60.9 ± 6.93 | 61.0 ± 4 | 75.4 ± 12.81 | 80.2 ± 15.32 |