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BI.1 regulates apoptosis induce by PST accumulation. In oyster stress cells, CYP1A can directly or indirectly neutralize and convert PST to ROS. ROS induces the expression of the protein Bax, which promote the intrinsic apoptotic pathway. BI-1 can inhibit Bax and could limit CYP1A production of ROS preventing the apoptosis.
