Table 2.
Five-Year Local Recurrence Based on Patient Prognostic Factors and Univariable Analysis
| Characteristic | No. | % | LR at 5 Years (%) | 95% CI (%) |
P* | |
|---|---|---|---|---|---|---|
| Lower | Upper | |||||
| Treatment | ||||||
| Conventional EBRT | 154 | 48 | 15.1 | 9.2 | 20.9 | .05 |
| IMRT | 165 | 52 | 7.6 | 3.4 | 11.8 | |
| Time period | .09 | |||||
| Prior to 2002 | 97 | 80 | 71.2 | 88.8 | ||
| 2002-2006 | 130 | 91.1 | 85.7 | 96.5 | ||
| After 2006 | 92 | 91.4 | 85 | 97.8 | ||
| Age, years | ||||||
| ≤ 50 | 119 | 37 | 7.0 | 2.3 | 11.7 | .05 |
| > 50 | 200 | 63 | 13.9 | 8.9 | 18.9 | |
| Extremity location | ||||||
| Upper | 81 | 25 | 10.7 | 3.6 | 17.8 | .97 |
| Lower | 238 | 75 | 11.7 | 7.4 | 16.0 | |
| Depth | ||||||
| Superficial | 26 | 8 | 10.4 | 0.0 | 20.7 | .54 |
| Deep | 293 | 92 | 11.8 | 7.9 | 15.6 | |
| Tumor size | ||||||
| ≤ 10 cm | 176 | 55 | 7.8 | 3.5 | 12.0 | .05 |
| > 10 cm | 143 | 45 | 16.0 | 9.8 | 22.1 | |
| Positive/close margin | ||||||
| No | 173 | 54 | 8.7 | 4.3 | 13.0 | .17 |
| Yes | 146 | 46 | 14.8 | 8.7 | 20.9 | |
| Grade | ||||||
| Low | 56 | 18 | 7.9 | 0.3 | 15.5 | .37 |
| High | 263 | 82 | 12.2 | 8.0 | 16.3 | |
| Histology | ||||||
| Malignant fibrous histiocytoma† | 117 | 37 | 15 | 8.3 | 21.6 | .17 |
| Liposarcoma | 90 | 28 | 7 | 1.6 | 12.4 | |
| Synovial | 30 | 9 | 4 | 0 | 11.4 | |
| Leiomyosarcoma | 15 | 5 | 21 | 0 | 42.8 | |
| Other | 67 | 21 | 13 | 3.6 | 22.7 | |
| Radiation sequence | ||||||
| Pre | 40 | 13 | 10.8 | 0.5 | 21.0 | .74 |
| Post | 279 | 87 | 11.5 | 7.6 | 15.4 | |
| Adjuvant chemotherapy | ||||||
| No | 240 | 75 | 10.5 | 6.4 | 14.5 | .51 |
| Yes | 79 | 25 | 14.5 | 6.4 | 22.5 | |
Abbreviations: EBRT, external beam radiation therapy; IMRT, intensity-modulated radiation therapy; LR, local recurrence.
*
P value determined by Gray's test.
†
Includes myxofibrosarcoma.