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. Author manuscript; available in PMC: 2014 Sep 30.
Published in final edited form as: Pediatr Diabetes. 2011 Dec 13;13(5):408–418. doi: 10.1111/j.1399-5448.2011.00836.x

Fig. 1.

Fig. 1

Genotypic and phenotypic characterizations of complement C4 in the MHC class III region. A. Genomic TaqI RFLP to determine RP-C4-CYP21-TNX (RCCX) modules and copy-number variations of long and short C4 genes. B.PshAI-PvuII RFLP to elucidate the relative gene copy-numbers of C4A and C4B. C. High voltage agarose gel electrophoresis (HVAGE) and immunofixation of plasma protein to demonstrate polymorphisms of native C4A and C4B allotypes based on gross differences in electric charges. D. Interpretations of C4 genotypes and phenotypes in eight T1D patients shown in panels A to C.