TABLE 1.

Demographics, complement and HLA-DRB1 in new onset T1D

Patient	Sex	Age (yrs)	BMI (kg/m2;	[C3] (mg/L)	[C4] (mg/L)	[C4]-9 mon. (mg/L)	Total C4 CNV	C4A CNV	C4B CNV	RCCX H1	RCCX H2	DRB1 H1	DRB1 H2
1	M	9	15.7	1532	158	188	3	0	3	LL	S	17(3)*	13.1
2	F	11	16.3	1137	187	138	4	3	1	LL	LL	17(3)	4
3	M	10	15.6	1592	456	406	4	2	2	LS	LS	1	4
4	M	12	23.0	1414	254	236	4	3	1	LL	LL	4	13
6	M	9	23.9	2681	504	556	5	2	3	LL	LLS	7	9
7	M	13	17.2	1157	242	434	3	1	2	LS	S	17(3)*	4
8	M	11	17.3	1288	179	362	4	4	0	LL	LL	1	4
9	M	4	14.4	2244	202	266	3	1	2	LL	S	17(3)*	4
10	M	9	15.5	1222	209	271	3	1	2	LL	S	17(3)*	11
11	M	10	17.5	1855	341	n.d.	3	1	2	LL	S	17(3)*	4
12	M	14	15.4	849	181	128	4	3	1	LL	LS	1	4
13	M	14	17.0	1355	241	195	4	2	2	LS	LS	7	8
14	M	13	12.5	849	273	n.d.	3	1	2	LL	S	17(3)*	4
15	M	10	21.8	1493	371	484	5	3	2	LS	LSS	12	13.1
16	F	12	17.0	1031	163	102	2	1	1	L	S	1	17(3)
17	M	14	15.5	1493	469	222	5	2	3	LS	LSS	1	4
18	M	9	17.3	1306	278	261	4	3	1	LL	LL	4	4
19	M	12	16.3	1183	289	276	4	2	2	LS	LS	7	8
20	M	16	29.2	732	245	279	4	3	1	LL	LS	4	7
21	M	8	23.9	1984	298	399	4	2	2	LS	LS	17(3)	17(3)
22	M	4	19.4	1006	297	397	6	3	3	LSS	LLS	7	13.1
23	M	10	25.4	1306	335	n.d.	3	1	2	LL	S	4	4
24	M	16	17.6	1006	197	237	4	3	1	LL	LL	4	12
25	F	11	21.3	1123	236	196	3	1	2	LS	S	4	15
26	F	8	17.1	2441	404	321	4	2	2	LS	LS	4	4
27	M	11	17.5	485	158	246	3	2	1	LS	L	13.1	1
28	M	6	19.7	1006	153	323	3	2	1	LL	L	4	7
30	M	12	15.4	1386	341	340	5	3	2	LSS	LL	1	7
31	M	7	15.2	912	198	n.d.	2	0	2	S	S	17(3)*	17(3)*
32	M	13	19.8	1386	150	175	2	1	1	L	S	17(3)*	17(3)
33	M	17	20.7	1761	244	n.d.	4	3	1	LL	LS	13.1	12
34	F	3	14.9	727	<30	n.d.	3	2	1	LS	L	13.1	4
35	M	16	17.0	735	135	n.d.	3	1	2	LL	S	17(3)*	14.1

^*an asterisk signifies an extended haplotype with HLA-DR3 and C4A deficiency; [C4], C4 protein concentration; [C3], C3 protein concentration; H1, haplotype 1; H2, haplotype 2; n.d., not determined.