Table 1.
Characteristics of the dexamethasone pharmacokinetic data collected from the literature
| Species | Study design | Dexamethasone phosphate dose |
Vss (l/kg) |
CL (l/h/kg) |
Reference |
|---|---|---|---|---|---|
| Male Sprague-Dawley rat | Serial sampling | 1 and 3 mg/kg | 1.1 | 0.19 | [4] |
| Male adrenalectomized Wistar rat | Giant rat study | 0.1 mg/kg | 1.2 | 0.16 | [6] |
| Female Wistar rat | Serial sampling | 1 mg/kg | 0.78 | 0.23 | Current study |
| Pregnant Sprague-Dawley rat | Giant rat study | 1.9 mg/kg | 0.87 | 0.19 | [14] |
| Human | Serial sampling | 4.8 mg (4 mg dexamethasone) | 1.2 | 0.18 | [1] |