. Author manuscript; available in PMC: 2014 Sep 30.

Published in final edited form as: Biopharm Drug Dispos. 2005 Apr;26(3):85–91. doi: 10.1002/bdd.435

Table 2.

Dexamethasone pharmacokinetic parameters in female rats after intramuscular and intravenous administration of 1 mg/kg dexamethasone phosphate. Values in parenthesis represents CV% of the estimate and is not reflective of inter-animal variability

Parameter	Source	Individual fit	Simultaneous fit
		Parameter estimate (CV%)	Parameter estimate (CV%)
CL (l/h/kg)	IV	0.26 (7.8)	0.23 (14)
V_c (l/kg)	IV	0.75 (3.4)	0.78 (6.4)
F	N/A	N/A	0.86 (10)
k_a (h⁻¹)	IM	3.8 (47)	2.9 (29)
CL/F (l/h/kg)	IM	0.22 (31)	N/A
V_c/F (l/kg)	IM	1.0 (17)	N/A