Table I.
Corticosterone Circadian Rhythm in Normal Rats and Pharmacokinetics of Hydrocortisone/Dexamethasone in ADX Rats
| Parameter | Definition | Value | ||
|---|---|---|---|---|
| CS circadian rhythm | ||||
| T (h) | Biorhythmic period | 24 | ||
| n | Number of harmonics | 0 | 1 | 2 |
| an | Fourier coefficient | 116 | −121 | 38.8 |
| bn | Fourier coefficient | – | −41.1 | 1.58 |
| Hydrocortisone/dexamethasone pharmacokinetics | ||||
| C1 (µg ml−1) | Intercept coefficient | 85.1a/0.0582b | ||
| C2 (µg ml−1) | Intercept coefficient | 2.22a/0.0753b | ||
| λ1 (h−1) | Slope coefficient | 5.04a/1.66b | ||
| λ2 (h−1) | Slope coefficient | 0.542a/0.125b | ||
a
Hydrocortisone 50 mg kg−1 i.v. injection.
b
Dexamethasone 0.1 mg kg−1 i.v. injection.