. Author manuscript; available in PMC: 2014 Sep 30.

Published in final edited form as: Pharm Res. 2006 Feb 2;23(4):670–679. doi: 10.1007/s11095-005-9608-3

Table II.

Estimated and Fixed Pharmacodynamic Parameters for GS Modeling

Parameter	Definition	Value	CV (%)
α	Intracellular/plasma ratio	0.0175	67
B_{max_normal} (fmol mg protein⁻¹)	Cytosolic GR density in normal rats	44.0	90
τ (h)	Mean transit time	1.13	65
k_{dgr_GS_m} (h⁻¹)	GS mRNA degradation rate	0.203	41
S [(fmol/mg protein)⁻¹]	Stimulatory coefficient	0.142	28
k_{dgr_GS} (h⁻¹)	GS Degradation Rate	0.0512	19
k_{syn_GS_m_normal} (fmol g tissue⁻¹ h⁻¹)	GS mRNA synthesis rate in normal rats	0.267	109
k_{syn_GS_normal} (µmol min⁻¹ g protein⁻¹ h⁻¹)	GS synthesis rate in normal rats	0.210	20
k_{syn_GS_m_ADX} (fmol g tissue⁻¹ h⁻¹)	GS mRNA synthesis rate in ADX rats	0.487	–^a
k_{syn_GS_ADX} (µmol min⁻¹ g protein⁻¹ h⁻¹)	GS synthesis rate in ADX rats	0.370	–^a
K_{d_CS} (nM)	Corticosterone dissociation constant	5.13	Fixed
K_{d_HYD} (nM)	Hydrocortisone dissociation constant	13.5	Fixed
K_{d_DEX} (nM)	Dexamethasone dissociation constant	1.32	Fixed
B_{max_ADX} (fmol mg protein⁻¹)	Cytosolic GR density in ADX rats	66.3	Fixed
$G S_{m_A D X}^{0}$ (fmol g tissue⁻¹)	GS mRNA baseline in ADX rats	2.43	Fixed
$G S_{A D X}^{0}$ (µmol min⁻¹ g protein⁻¹)	GS activity baseline in ADX rats	17.6	Fixed

Secondary parameter calculated from degradation rate and baseline.