Table 2.
Betamethasone Pharmacokinetic Parameters
| 170 µg/kg BM Phosphate |
170 µg/kg BM Phosphate/Acetate |
|
|---|---|---|
| Average body weight (kg) | 54.00 | 53.75 |
| Cmax (ng/mL) | 208.2 | 111.0 |
| AUC (ng·h/mL) | 559.5 | 287.7 |
| Terminal t1/2 (h) | 2.75 | 3.04 |
| V/FBMp (L/kg) | 1.20 | 2.46 |
| CL/FBMp (L·h−1·kg−1) | 0.30 | 0.56 |
| Relative bioavailability (FBMp/a/FBMp) | 51% |
Cmax, highest concentration observed; AUC, area under the curve; V/F, apparent volume of distribution; CL/F, apparent clearance; BMp, betamethasone phosphate; BMp/a, betamethasone phosphate acetate.
Values are obtained from the average maternal plasma concentration after 170 µg/kg betamethasone phosphate (n=6) and betamethasone phosphate acetate (n=4).