Table 3.
Treatment uptake as defined by percentage of hepatitis C RNA-positive study participants who received treatment
| Author, year | % treated (# treated/# of treatment candidates) | SVR (%) (# with sustained viral response/# treated) |
|---|---|---|
| Backmund et al, 2001 | 50% (50/100) | Intent-to-treat: 36% (18/50) |
| Broers et al, 2005 | 61% (11/18) | Intent-to-treat: 56% (6/11) As-treated: 100% (3/3) |
| Cournot et al, 2004 | 54% (81/151) | Intent-to-treat: 26% (26/99)1 |
| Cullen et al, 2007 | 10% (3/29) | NA |
| Ebner et al, 2009 | 23% (17/75) | Intent-to-treat: 88% (15/17) As-treated: 88% (15/17) |
| Gazdag et al, 2010 | 47% (39/83) | NA |
| Grando-Lemaire et al, 2002 | 28% (27/97) | Intent-to-treat: 19% (5/27) As-treated: 33% (5/15) |
| Guadagnino et al, 2007 | 31% (53/169) | Intent-to-treat: 55% (29/53) As-treated: 85% (29/34) |
| Hernandez et al, 2009 | 0% (0/4) | NA |
| Jack et al, 2009 | 25% (30/118) | Intent-to-treat: 62% (13/21) As-treated: 77% (13/17) |
| Jowett et al, 2000 | 29% (50/172) | Intent-to-treat: 36% (18/50) |
| Kieran et al, 2011 | 21% (67/327) | Intent-to-treat: 43% (29/67) |
| Lindenburg et al, 2011 | 30% (58/196) | Intent-to-treat: 65% (37/57) As-treated: 77% (37/48) |
| McCormick et al, 2008 | 46% (6/13) | Intent-to-treat: 83% (5/6) As-treated: 83% (5/6) |
| Moussalli et al, 20102 | 2% (2/113) | NA |
| Moussalli et al, 20102 | 38% (85/224) | Intent-to-treat: 43% (37/85) |
| Perez-Alvarez et al, 2012 | 56% (15/27) | NA |
| Perut et al, 2009 | 9% (12/137) | NA |
| Reiberger et al, 2011 | 32% (201/637) | NA |
| van der Veen, 2009 | 48% (35/73) | NA |
| Wilkinson et al, 2008 | 14% (63/441) | As-treated: 51% (25/49)3 |
| Witteck et al, 2011 | 15% (29/193) | Intent-to-treat: 52% (13/25) |
1. Calculated according to the number of treatment outcomes (N=99) rather than the number of patients who initiated therapy (N=81)
2. The study by Moussalli et al includes separate study populations for an observational phase (N=113) and an intervention phase (N=224), and those study populations are represented by two separate records in this table.
3. Calculated according to the number of treatment outcomes (N=49) rather than the number of patients who completed therapy (N=58)